Discovery of an entropically-driven small molecule streptavidin binder from nucleic acid-encoded libraries.
نویسندگان
چکیده
Dehydrocholic acid was identified as a selective streptavidin binder from a PNA-tagged library. Isothermal calorimetry titration measurements showed this interaction to be entropically driven. Peptides tagged with dehydrocholic acid can be captured on a streptavidin resin and released under thermal conditions.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 10 8 شماره
صفحات -
تاریخ انتشار 2012